Key result
Following 4 weeks of treadmill training, FVB/NJ mice demonstrated significant increases in exercise capacity and physiologic cardiac growth (HW/TL 7.6 vs 6.3 mg/mm, p<0.001), whereas C57BL/6J mice showed no improvements due to progressive loss of compliance.
Population
15-week-old male C57BL/6J and FVB/NJ mice
Comparison
4-week forced treadmill running protocol during… vs Sedentary mice of the same strains
Design
Preclinical, assigned randomly by strain to sedentary or exercise groups
Follow-up
4 weeks
Authors
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FVB/NJ mice enable reliable treadmill studies of cardiac growth; leaves open optimal strains for other exercise or species models.
Absolute Event Rate: 7.6% vs 6.3%
p-value: p=<0.001
FVB/NJ mice are a robust and compliant model for studying cardiac adaptations to treadmill exercise, unlike the commonly used C57BL/6J strain.
Gibb et al. (2016) studied Healthy mice (C57BL/6J and FVB/NJ strains) (n=60). Treadmill exercise training vs. Sedentary control was evaluated on Heart weight-to-tibia length ratio (HW/TL) in FVB/NJ mice (Day Exercise vs Sedentary) (p=<0.001). Following 4 weeks of treadmill training, FVB/NJ mice demonstrated significant increases in exercise capacity and physiologic cardiac growth (HW/TL 7.6 vs 6.3 mg/mm, p<0.001), whereas C57BL/6J mice showed no improvements due to progressive loss of compliance.
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