Chlormequat Chloride (CCC) is a plant growth regulator widely used to enhance crop yield and value. However, excessive use of CCC may have adverse effects on human health. In this study, we utilized the fruit fly (Drosophila melanogaster) model to evaluate the effects of CCC on reproductive ability and certain growth indices. The results showed that CCC reduced reproductive capacity and prolonged developmental time but did not affect survival rate or puparium height. Additionally, this study demonstrated that CCC induces neurodegeneration in fruit fly brain cells through a DNA breakage mechanism. Thus, the fruit fly model can be used for toxicological screening, for elucidating the interactions between toxic substances and biological systems while providing a foundation for further research on higher animal models.
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Tuệ et al. (2025) studied this question.
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