Why the study?
How do cardiovascular reflexes respond to Valsalva's manoeuvre and head-up tilt in Parkinsonian patients, and do they correlate with age or disease severity?
How do cardiovascular reflexes respond to Valsalva's manoeuvre and head-up tilt in Parkinsonian patients, and do they correlate with age or disease severity?
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In Parkinsonian patients not treated with levodopa, cardiovascular reflex deterioration correlates with advancing age rather than the duration or severity of the disease.
Cardiovascular reflex activity has been studied in thirty Parkinsonian patients, none of who had received levodopa or sympatholytic drugs. 2. Changes in blood pressure and pulse rate in response to Valsalva's manoeuvre and head-up tilt were investigated by intra-arterial recording. 3. Cardiovascular reflex function deteriorated with advancing age, but there was no correlation with either the duration or the severity of the Parkinsonism. 4. These results are discussed in relation to previous reports of hypotension in Parkinsonism.
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Reid et al. (1971) studied this question.
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