The inhibitory activity of stilbenes isolated from medicinal plants on cell adhesion molecules on the surface of THP-1 human monocytic cell lines was investigated. Among ten stilbenes tested, four stilbenes displayed a significant inhibitory activity on the expression of both intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1). A cell-to-cell adhesion assay showed that 3,5-dihydroxy-4′-methoxystilbene and 2,3,4′,5-tetrahydroxystilbene-2-O-β-D-glucopyranoside as well as resveratrol blocked significantly TNF-α-inducing cell-cell adhesion between human umbilical vein endothelial cells (HUVEC) and THP-1 cells. Abbreviations ELISA:Enzyme linked immunoadsorbent assayFBS:Fetal bovine serumHUVEC:Human umbilical vein endothelial cellICAM-1:Intercellular adhesion molecule-1OPD: O -Phenylenediamine dihydrochloridePBS:Phosphate buffered salineTNF-α:Tumor necrosis factor-αVCAM-1:Vascular cell adhesion molecule-1
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Ahn et al. (2000) studied this question.