Rationale and Design of MAGNET (Mitochondria-AGing in NorthErn Taiwan) Study: A Community-based Cohort Investigating Mitochondria-related Aging and Cardiovascular Diseases in Suburban Areas of Northern Taiwan

Background: Aging is known to play a key role in the development of cardiovascular diseases (CVDs). Although aging is associated with mitochondria dysfunction, the impact of mitochondria-related aging on CVDs has remained unclear in Taiwan. Methods: The Mitochondria-AGing in NorthErn Taiwan (MAGNET) study, a prospective study, was initiated in December 2010 to investigate the prevalence, determinants and the progress of CVDs and related risks in a community-dwelling sample of about 3000 men and women from suburban areas of northern Taiwan. The middle-aged population comprises the majority of the whole cohort in a 3-year collection period. This study also examines a link between baseline characteristics and the development of subclinical atherosclerosis. Data obtained will include information regarding baseline demographics, body surface electrocardiography, blood bio-specimen components, measurement of cardiac and carotid structure and function by ultrasonography, socioeconomic status, life styles, and life quality scoring including short-form SF-36. Additional survey of blood samples, including analysis of endothelial progenitor cells and the mitochondria function, and biomarkers, for a nested case-control study will be performed. All participants will be followed for incidence and characterization of related cardiovascular events. Conclusion: This study is expected to clarify the role of mitochondria-related aging in the development of CVDs and functional changes in sub-urban areas of Taiwan.