Key result
Intraoperative administration of D-fructose-1,6-diphosphate mitigated the postoperative decrease in erythrocyte indices such as MCV compared to standard therapy in patients undergoing cardiopulmonary bypass.
Why the study?
To analyse the functional state of red blood cells in patients with surgical pathology of the aorta after surgical intervention using cardiopulmonary bypass.
Does the addition of meglumin sodium succinate or D-fructose-1,6-diphosphate sodium hydrate improve erythrocyte indices in patients undergoing surgery for aortic pathology with cardiopulmonary bypass?
Cohort (n=118)
Yes
Does the addition of meglumin sodium succinate or D-fructose-1,6-diphosphate sodium hydrate improve erythrocyte indices in patients undergoing surgery for aortic pathology with cardiopulmonary bypass?
Cardiopulmonary bypass negatively affects erythrocyte indices, but the addition of D-fructose-1,6-diphosphate sodium hydrate may promote faster recovery of red blood cell distribution width.
The aim is to analyse the functional state of red blood cells in patients with surgical pathology of the aorta after surgical intervention using cardiopulmonary bypass.Materials and Methods. 118 patients with surgical aortic pathology (SAP) were examined. Patients were divided into 2 groups. Group I included 46 patients who were additionally prescribed a solution of meglumin sodium succinate (reamberin), group II included 46 patients who were additionally assigned a solution of D-fructose-1,6-diphosphate sodium hydrate (esophosphine). Erythrocyte indices were analyzed: MCV (mean erythrocyte volume), MCH (mean hemoglobin in erythrocyte), MCHC (mean hemoglobin concentration in erythrocyte mass) and RDW (erythrocyte mean volume ratio).Result. When analyzing the dynamics of the indicator of the width of the distribution of erythrocytes by volume (coefficient of the average volume of the erythrocyte) in the blood of patients with groups K, I and II, no significant differences were found between the groups. Despite the absence of statistically significant differences in the RDW index between the groups on a daily basis and in comparison with the starting values, nevertheless, in patients of group II, the recovery of its numbers was faster compared to others. Considering that patients of group II differed in prescribing an additional substance to the main treatment protocol - D-fructose-1,6-diphosphate sodium hydrate salt - its pharmacodynamic effect can be considered positive for the erythrocyte membrane elasticity, their elasticity and hemolytic resistance.Conclusions. It can be argued that the mere fact of anesthesia support using cardiopulmonary bypass negatively affects the state of erythrocyte indices: МСV, МСН, МСНС, RDW. The study provides a vector for the appointment during surgery additional pharmacological substances that would have a positive impact on these indicators
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Khyzhniak et al. (2019) conducted a cohort in Surgical pathology of the aorta requiring cardiopulmonary bypass (n=118). D-fructose-1,6-diphosphate (Esafosfina) vs. Standard intensive therapy was evaluated on Mean corpuscular volume (MCV) at 12 hours post-operation in micrometers. Intraoperative administration of D-fructose-1,6-diphosphate mitigated the postoperative decrease in erythrocyte indices such as MCV compared to standard therapy in patients undergoing cardiopulmonary bypass.
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