Green N-Methylation of Electron Deficient Pyrroles with Dimethylcarbonate

The N -methylation of electron-deficient pyrroles was affected using dimethyl carbonate in the presence of DMF and catalytic DABCO. This alkylation methodology has proven useful for the alkylation of a variety of pyrroles in 72−98% yields and is considered to be green chemistry relative to the more common use of methyl halides or dimethyl sulfate.