Treatment of Refractory Melasma with Oral Tranexamic acid: A Case Report

Melasma, an acquired disorder of hyperpigmentation is common in Indians. Though topical skin lightening agents are available, the success rates are often variable. Management of melasma is a challenge and the search for a safe and effective therapy continues. Many studies suggested the use of oral tranexamic acid (TA) as a treatment modality for melasma. Herein we report a case of female patient with refractory melasma who showed an improvement with a combination of oral tranexamic acid 250 mg and pine bark extract 50 mg twice daily during 8 weeks treatment period. Also, there was no recurrence seen in 3 month follow-up period. This treatment modality was well tolerated.