Optimal conditions are described for the reversed phase HPLC separation of UV absorbing constituents including peptides and proteins in urine. Metabolic profiles have been obtained for urinary constituents in the molecular weight range > 1000, 1000–10,000, and > 10,000 for healthy controls, patients with rheumatoid arthritis and osteoarthritis. A computer program was employed to compare individual and groups of profiles. Considerable variation was encountered in the patterns of constituents and comparison of the metabolic profiles revealed no diagnostically significant differences between the various groups of subjects.
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Clark et al. (1980) studied this question.
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