Catalytic Staudinger—Vilarrasa Reaction for the Direct Ligation of Carboxylic Acids and Azides

2,2'-Dipyridyl diselenide (PySeSePy) is the catalyst or activator of choice for the direct reaction of carboxylic acids with azides and trimethylphosphine at room temperature. The mechanism of the process, which is not an aza-Wittig reaction, has been elucidated. Original language English Pages (from-to) 2203-2206 Number of pages 4 Journal The Journal of organic chemistry Volume 74 DOIs https://doi.org/10.1021/jo802825e Publication status Published - 2009 Keywords native chemical ligation oxidation-reduction condensation aza-wittig reaction one-pot preparation 2 redox reactions peptide synthesis synthetic tricks natural-products puromycin analogs glycosyl azides