What question did this study set out to answer?

To identify the cellular and physiological mechanisms by which adenosine 5'-monophosphate induces hypothermia and provides protection against severe hypoxia.

August 27, 2019ShockOpen Access

Adenosine 5’-Monophosphate Protects from Hypoxia by Lowering Mitochondrial Metabolism and Oxygen Demand

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To identify the cellular and physiological mechanisms by which adenosine 5'-monophosphate induces hypothermia and provides protection against severe hypoxia.
Administered adenosine 5'-monophosphate via intraperitoneal injection to adult male and female C57BL/6J mice exposed to hypoxic (6% O2) or anoxic (<1% O2) gas environments.
Treated mouse and human neuronal cell cultures with adenosine 5'-monophosphate to measure mitochondrial membrane potential, calcium signaling, and metabolic enzyme activation.
Adenosine 5'-monophosphate activated AMP-activated protein kinase and suppressed mTORC1, dose-dependently reducing mitochondrial membrane potential and calcium signaling in resting and stimulated neurons.
Intraperitoneal pretreatment with adenosine 5'-monophosphate nearly doubled mouse survival duration under hypoxic and anoxic conditions while transiently depressing heart rate, breathing rate, and body temperature.

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Implication

Preclinical study shows that adenosine monophosphate lowers mitochondrial oxygen demand and doubles hypoxic survival in mice, indicating a potential pharmacological strategy for ischemia.

Cite This Study

Kondo et al. (2019) studied this question.

synapsesocial.com/papers/6a961d67693ea9c5f4ee6ffd https://doi.org/10.1097/shk.0000000000001440

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Implication

Preclinical study shows that adenosine monophosphate lowers mitochondrial oxygen demand and doubles hypoxic survival in mice, indicating a potential pharmacological strategy for ischemia.

Adenosine 5’-Monophosphate Protects from Hypoxia by Lowering Mitochondrial Metabolism and Oxygen Demand

Key Points

Discussion

Implication

Cite This Study

Adenosine 5’-Monophosphate Protects from Hypoxia by Lowering Mitochondrial Metabolism and Oxygen Demand

Key Points

Discussion

Implication

Cite This Study

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