Key result
Molecular dynamics simulations demonstrate that chemical substitutions in the KcsA selectivity filter do not preclude constricted-like conformations, supporting them as the basis for C-type inactivation.
Population
Atomic models of the KcsA potassium channel
Design
Preclinical
Authors
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Supports K+ channel gating models; leaves open validation in native mammalian or human cardiac channels.
Molecular dynamics simulations confirm that the constricted conformation of the selectivity filter is the structural basis for C-type inactivation in potassium channels.
Li et al. (2017) studied Potassium channel C-type inactivation. Chemical substitutions in KcsA selectivity filter vs. Wild-type KcsA was evaluated on Conformational state of the selectivity filter. Molecular dynamics simulations demonstrate that chemical substitutions in the KcsA selectivity filter do not preclude constricted-like conformations, supporting them as the basis for C-type inactivation.
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