The preparation of metallocene sulfoxides and their ortho ‐diastereoselective functionalization are described. The applications of enantiopure 1,2‐ and 1,3‐disubstituted metallocenes are reviewed, with special emphasis on the preparation of ligands for asymmetric catalysis. The sulfoxide functionality is a useful, traceless, chiral diastereoselective ortho ‐directing group, as explained in the article. It allows one to synthesize a wide range of enantiopure metallocenes with planar chirality and predictible configuration. Most of the examples are related to the ferrocene area.
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Ferber et al. (2007) studied this question.
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