per gadolinium]. Additionally, gadolinium-based conjugates had greater tumor accumulation in the U87 tumors in mice, and therefore, offered enhanced signal intensity (SI) to MRI. The best in vivo imaging behaviors were mediated by cRGD functionalized conjugates. The 2 polymeric conjugates presented no significant side effects as measured by cytotoxicity, hemocompatibility, and in vivo toxicity studies. Therefore, owing to their great efficacy and good biosafety, the biodegradable block HPMA copolymer-Gd(iii) conjugates are promising as targeting MRI probes.
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Li et al. (2017) studied this question.
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