Key result
Magnetically levitated bearingless centrifugal pumps caused considerably lower mechanical stress to CHO cells than peristaltic and diaphragm pumps.
Population
Transfected Chinese hamster ovary (CHO) suspension cells
Comparison
Reusable and single-use magnetically levitated… vs Peristaltic and 4-piston diaphragm pumps
Design
Preclinical
Authors
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May inform pump selection to limit cell damage in bioprocessing; leaves open translation to clinical cardiovascular devices.
Magnetically levitated bearingless centrifugal pumps induce less mechanical stress and cell death in CHO suspension cells compared to standard peristaltic and diaphragm pumps.
Blaschczok et al. (2012) studied CHO suspension cells. Magnetically levitated, bearingless centrifugal pumps vs. Peristaltic and 4-piston diaphragm pump was evaluated on Cell death rates. Magnetically levitated bearingless centrifugal pumps caused considerably lower mechanical stress to CHO cells than peristaltic and diaphragm pumps.
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