Key result
Pistachio consumption significantly improved brachial artery diameter (WMD +0.04%; p<0.001) but did not significantly change flow-mediated dilatation (WMD +0.28%; p=0.525).
Why the study?
Does pistachio consumption improve endothelial reactivity (FMD and BAD) in participants of controlled-feeding clinical studies?
Meta-Analysis
Does pistachio consumption improve endothelial reactivity (FMD and BAD) in participants of controlled-feeding clinical studies?
Mean Difference: 0.28 (95% CI -0.58–1.13)
p-value: p=0.525
Pistachio consumption improves brachial artery diameter but does not significantly affect flow-mediated dilatation, suggesting a partial benefit on endothelial reactivity.
Pistachios selectively increase BAD without FMD change; extends controlled-trial evidence for partial endothelial effects of nuts.
BACKGROUND: Results of previous clinical trials evaluating the effect of pistachio supplementation on endothelial reactivity (ER) are controversial. AIMS: We aimed to assess the impact of pistachio on ER through systematic review of literature and meta-analysis of available randomized, controlled-feeding clinical studies (RCTs). METHODS: The literature search included SCOPUS, PubMed-Medline, ISI Web of Science and Google Scholar databases up to 1st August 2017 to identify RCTs investigating the impact of pistachio on ER. Two independent reviewers extracted data on study characteristics, methods and outcomes. Overall, the impact of pistachio on ER was reported in 4 trials. RESULTS: The meta-analysis did not suggest a significant change in brachial artery flow-mediated dilatation (FMD) (WMD: +0.28%; 95%CI: -0.58, 1.13; p = 0.525) while brachial artery diameter (BAD) improved (WMD: +0.04%; 95%CI: 0.03, 0.06; p<0.001) following pistachios consumption. CONCLUSION: The present meta-analysis suggests a significant effect of pistachios on ER, affecting BAD but not FMD.
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Fogacci et al. (2017) reported a meta-analysis. Pistachio vs. Control was evaluated on Brachial artery flow-mediated dilatation (FMD) (WMD +0.28%, 95% CI -0.58, 1.13, p=0.525). Pistachio consumption significantly improved brachial artery diameter (WMD +0.04%; p<0.001) but did not significantly change flow-mediated dilatation (WMD +0.28%; p=0.525).
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