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Replacement of the butyrolactone unit of the natural products with a quinone subunit has resulted in the synthesis of natural-product hybrids of quinone–mucocin (1). These compounds, which are combined from partial structures of annonaceous acetogenins and ubiquinone, are very potent inhibitors of complex I (an NADH ubiquinone oxidoreductase) from mitochondrial membranes.
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Hoppen et al. (2000) studied this question.
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