Structure simplification with conservation of the essential functionalities for biological activity has been achieved with the design and synthesis of four analogues of annonaceous acetogenins. The compounds ((15 R/S, 24 R/S)-1) are easily synthesized with L- and/or D-glyceraldehyde acetonide and L-lactic acid as the chiral carbon sources. Preliminary biological tests of these compounds at cellular level show remarkable, selective antitumor activity.
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Zeng et al. (2000) studied this question.