Synthetic Studies of Annonaceous Acetogenins.

Synthetic studies of annonaceous acetogenins, that are endemic to certain plants of Annonaceae and exhibit a number of interesting biological activities including cytotoxic, antitumor, pesticidal, antiinfective properties are described. We synthesized the following types of compounds : 1) degradation products of annonaceous acetogenins (muricatacin, squamostanal A), 2) monotetrahydrofuranic acetogenins (solamin, reticulatacin, corossoline), 3) oxirane ring-containing acetogenins (epoxyrollin A, diepomuricanin), 4) nonadjacent bis-tetrahydrofuranic acetogenins (4-deoxygigantecin).