Hypospadias Is Related to Birth Weight in Discordant Monozygotic Twins

No AccessJournal of UrologyPediatric Urology1 Dec 1998HYPOSPADIAS IS RELATED TO BIRTH WEIGHT IN DISCORDANT MONOZYGOTIC TWINS LOUISE FREDELL, PAUL LICHTENSTEIN, NANCY L. PEDERSEN, JAN SVENSSON, and AGNETA NORDENSKJOLD LOUISE FREDELLLOUISE FREDELL , PAUL LICHTENSTEINPAUL LICHTENSTEIN , NANCY L. PEDERSENNANCY L. PEDERSEN , JAN SVENSSONJAN SVENSSON , and AGNETA NORDENSKJOLDAGNETA NORDENSKJOLD View All Author Informationhttps://doi.org/10.1016/S0022-5347(01)62294-8AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: Hypospadias is a common urogenital malformation in boys. The etiology is unknown but genetic and environmental factors are involved. Because monozygotic twins have the same genetic constitution, we studied disease discordant twin pairs to evaluate environmental risk factors while controlling for genetic effects. Materials and Methods: We used questionnaires to identify 28 male twins discordant for hypospadias at 4 pediatric surgical clinics in Sweden. Using deoxyribonucleic acid fingerprinting, and histopathological examination of the placenta and fetal membranes 18 twin pairs were diagnosed as monozygotic. Results: In 16 of the 18 monozygotic pairs discordant for hypospadias the twin with the lowest birth weight has hypospadias. Mean difference in birth weight was 498 gm. (t = 3.8, p <0.01). Conclusions: Environmental factors associated with low birth weight are involved in the etiology of hypospadias. References 1 : A joint international study on the epidemiology of hypospadias. Acta Paed. Scand.1986; 324: 1. Google Scholar 2 : Genetic and environmental factors in hypospadias. J. Med. Genet.1990; 27: 559. Google Scholar 3 : Study of the incidence of hypospadias in Rochester, Minnesota, 1940-1970, and a case-control comparison of possible etiologic factors. Mayo Clin. Proc.1974; 49: 52. 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Google Scholar From the Departments of Molecular Medicine and Pediatric Surgery, Karolinska Hospital and Division of Genetic Epidemiology, Institute of Environmental Medicine, Karolinska Institute, Stockholm, Sweden© 1998 by American Urological Association, Inc.FiguresReferencesRelatedDetailsCited byFossum M (2020) Editorial CommentJournal of Urology, VOL. 203, NO. 5, (1023-1023), Online publication date: 1-May-2020.Andersson M, Sjöström S, Wängqvist M, Örtqvist L, Nordenskjöld A and Holmdahl G (2018) Psychosocial and Sexual Outcomes in Adolescents following Surgery for Proximal Hypospadias in ChildhoodJournal of Urology, VOL. 200, NO. 6, (1362-1370), Online publication date: 1-Dec-2018.Canning D (2018) Re: Higher Incidence of Hypospadias in Monochorionic TwinsJournal of Urology, VOL. 195, NO. 3, (738-739), Online publication date: 1-Mar-2016.Nordenvall A, Frisén L, Nordenström A, Lichtenstein P and Nordenskjöld A (2018) Population Based Nationwide Study of Hypospadias in Sweden, 1973 to 2009: Incidence and Risk FactorsJournal of Urology, VOL. 191, NO. 3, (783-789), Online publication date: 1-Mar-2014.FRISÉN L, SÖDERHÄLL C, TAPPER-PERSSON M, LUTHMAN H, KOCKUM I and NORDENSKJÖLD A (2018) GENOME-WIDE LINKAGE ANALYSIS FOR HYPOSPADIAS SUSCEPTIBILITY GENESJournal of Urology, VOL. 172, NO. 4 Part 1, (1460-1463), Online publication date: 1-Oct-2004.FREDELL L, KOCKUM I, HANSSON E, HOLMNER S, LUNDQUIST L, LÄCKGREN G, PEDERSEN J, STENBERG A, WESTBACKE G and NORDENSKJÖLD A (2018) HEREDITY OF HYPOSPADIAS AND THE SIGNIFICANCE OF LOW BIRTH WEIGHTJournal of Urology, VOL. 167, NO. 3, (1423-1427), Online publication date: 1-Mar-2002. Volume 160Issue 6 Part 1December 1998Page: 2197-2199 Advertisement Copyright & Permissions© 1998 by American Urological Association, Inc.MetricsAuthor Information LOUISE FREDELL More articles by this author PAUL LICHTENSTEIN More articles by this author NANCY L. PEDERSEN More articles by this author JAN SVENSSON More articles by this author AGNETA NORDENSKJOLD More articles by this author Expand All Advertisement PDF downloadLoading ...