Expanding the donor pool for liver transplantation with marginal donors

The current supply of acceptable donor livers is not sufficient to meet the demands of listed patients awaiting transplantation resulting in thousands of deaths each year. Increased utilization of marginal livers may help alleviate this supply/demand mismatch by expanding the donor liver pool. The current status of liver transplantation using marginal donor grafts and efforts to optimize usage are discussed with attention to elderly donors, steatotic livers, donors after circulatory death, and split liver grafts. • There is a worldwide shortage of liver grafts. • Marginal liver grafts can potentially increase the organ pool. • With adequate recipient matching, marginal grafts can reduce mortality on liver transplant waiting lists.