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Patience pays off: 22 years ago Ley and co-workers started their project on the synthesis of azadirachtin (1)—a project which they recently completed successfully with the first total synthesis of this complex natural product. This milestone of natural product synthesis is acknowledged in this Highlight. Tig=tigloyl=(E)-2-methyl-2-butenoyl
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Johann Jauch (2007) studied this question.
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