Key result
Dandelion polysaccharide reduced iron burden and downregulated hepcidin expression in hepatoma cells and a mouse model by inhibiting the IL-6-activated JAK-STAT signaling pathway.
Why the study?
Iron overload is linked to hepatocellular carcinoma risk, but the effect of dandelion polysaccharide on iron metabolism and its underlying mechanism remained unclear.
Does dandelion polysaccharide reduce iron burden in hepatocellular carcinoma models?
Does dandelion polysaccharide reduce iron burden in hepatocellular carcinoma models?
Dandelion polysaccharide reduces iron burden and downregulates hepcidin via the JAK-STAT pathway in HCC models, suggesting potential as a therapeutic agent.
May support dandelion polysaccharide for HCC iron modulation; hypothesis-generating in animal models only.
Recent studies have claimed that iron overload was correlated with the risk of hepatocellular carcinoma (HCC), and our previous studies have also demonstrated that dandelion polysaccharide (DP) suppressed HCC cell line proliferation via causing cell cycle arrest and inhibiting the PI3K/AKT/mTOR pathway, but the effect of DP on metabolism is still not very clear. Here, we aim to clarify the effects of DP on iron metabolism and the underlying mechanism. In this study, we found that DP could reduce iron burden in hepatoma cells and grafted tumors. Hepcidin is a central regulator in iron metabolism. We confirmed that the expression of hepcidin in HCC tumor tissues was significantly higher than that in the adjacent nontumor tissues. The expression of hepcidin was downregulated in the liver of mouse model treatment with DP, as well as in hepatoma cells. Moreover, RNA sequencing and western blot data revealed that DP inhibited the IL-6-activated JAK-STAT signaling pathway. In summary, our results revealed that DP might be a new potential drug candidate for the regulation of iron burden and the treatment of HCC.
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Ren et al. (2021) studied Hepatocellular carcinoma. Dandelion polysaccharide was evaluated on Iron burden and hepcidin expression. Dandelion polysaccharide reduced iron burden and downregulated hepcidin expression in hepatoma cells and a mouse model by inhibiting the IL-6-activated JAK-STAT signaling pathway.
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