Key result
Gene expression profile scores significantly increased from 24.7 at 2-6 months to 28.8 at 7-12 months post-cardiac transplant, after which they remained stable.
Why the study?
How does time post cardiac transplant impact Gene Expression Profile scores in OHT recipients?
Population
Orthotopic Heart Transplant (OHT) recipients (unselected cohort, 32,043 tests analyzed)
Design
Cohort
Authors
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Time-dependent GEP changes in OHT warrant interpretive caution by interval; leaves open need for adjusted surveillance thresholds.
Cross-Sectional (n=9,272)
Yes
How does time post cardiac transplant impact Gene Expression Profile scores in OHT recipients?
Absolute Event Rate: 28.8% vs 24.7%
p-value: p=<0.0001
This study aims to characterize the effect of time post-transplant on Gene Expression Profile scores in a large cohort of heart transplant recipients.
Bethany A Austin PJ Arnold (2013) conducted a cross-sectional in Orthotopic Heart Transplant (n=9,272). Time post-cardiac transplant vs. Earlier time periods post-transplant (2-6 months) was evaluated on Gene Expression Profile (GEP) score (p=<0.0001). Gene expression profile scores significantly increased from 24.7 at 2-6 months to 28.8 at 7-12 months post-cardiac transplant, after which they remained stable.
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