Key result
Skeletal muscle tissue secretes more extracellular vesicles than white adipose tissue, with myofibers being a major source ex vivo but primarily remaining in their local environment in vivo.
Why the study?
Skeletal muscle and white adipose tissue are the two largest organs by mass, but their relative contribution to circulating extracellular vesicles is unknown.
Population
Mouse SkM and WAT tissue explants and dual fluorescent reporter mice
Comparison
SkM tissue vs WAT
Design
Ex vivo tissue explant and in vivo reporter mouse study
Authors
Loading...
SkM-EVs may emerge as tissue-specific biomarkers; hypothesis-generating for cardiometabolic applications pending human validation.
Estrada et al. (2020) studied this question. Skeletal muscle tissue vs. White adipose tissue was evaluated on Extracellular vesicle (EV) secretion. Skeletal muscle tissue secretes more extracellular vesicles than white adipose tissue, with myofibers being a major source ex vivo but primarily remaining in their local environment in vivo.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: