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A simple and efficient 3-acylation of indoles under microwave-heated and solvent-free conditions is developed. This general procedure uses neutral Al2O3 as a new, green and reusable catalyst giving good to high yields within short reaction times. Utilizing such an environmentally-benign methodology, a variety of indoles bearing electron-releasing or electron-withdrawing groups were conveniently acylated.
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Lai et al. (2013) studied this question.
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