Advances in Organocatalytic 1,6‐Addition Reactions: Enantioselective Construction of Remote Stereogenic Centers

Due to the competing 1,4‐addition reactions and the distance from the chirality information, the construction of a remote stereogenic center via 1,6‐addition reactions is often regarded as a great challenge in asymmetric synthesis. Recently, the use of organocatalysts has provided new, excellent alternatives to activate the remote δ‐position and facilitate the enantioselective 1,6‐addition reactions. In this regard, different new activation modes have been devised and new types of substrates have been employed. This review describes all the recent developments in this area. magnified image