Key result
Hypertension was associated with preserved diastolic function with aging compared to healthy elderly and CAD subjects, with a smaller annual increase in integrated score index (0.06 vs 0.20; P<0.05).
Why the study?
This 12-year study aimed to compare longitudinal changes in left ventricular diastolic dysfunction among healthy elderly individuals, patients with coronary artery disease, and patients with hypertension.
Cohort (n=130)
Under aggressive treatment, diastolic function appears to be relatively preserved in hypertensive subjects as they age compared to healthy elderly and CAD subjects.
Answers are grounded in this paper and cite their sources.
Suggests relatively preserved diastolic function with aging in treated HTN; extends observations but requires confirmation in prospective studies.
Background: This 12-year study aimed to compare the longitudinal change in left ventricular diastolic dysfunction (LVDD) between healthy elderly, coronary artery disease (CAD), and hypertension (HTN) patients. Methods: From 2008 to 2020, 1476 patients were included, and 3181 echocardiography examinations were conducted. Finally, 130 participants (36 healthy elderly (79.39 ± 9.51 years old), 51 with CAD (68.31 ± 12.09 years old), and 43 with HTN (68.31 ± 12.09 years old)) with more than a 10-year follow-up period were included in the final analysis. Results: The change in diastolic function was different among these subjects according to the integrated score index (elderly vs. HTN, p = 0.01; CAD vs. HTN, p = 0.01), septal E/e′ ratio (elderly vs. HTN, p < 0.001; CAD vs. HTN, p = 0.01), lateral E/e′ ratio (elderly vs. HTN, p < 0.001; CAD vs. HTN, p < 0.001), and NYHA functional class (elderly vs. HTN, p = 0.03; CAD vs. HTN, p < 0.001). Additionally, per one-year increase in age, the integrated score index increased 0.2 in the healthy elderly, 0.15 in the CAD, and 0.06 in the HTN patients (all p < 0.05). Conclusion: Under aggressive treatment, diastolic function was relatively preserved in HTN subjects with aging in comparison with elderly and CAD subjects.
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Chang et al. (2022) conducted a cohort in Left ventricular diastolic dysfunction (n=130). Hypertension (HTN) vs. Healthy elderly was evaluated on Annual increase in integrated score index (p=<0.05). Hypertension was associated with preserved diastolic function with aging compared to healthy elderly and CAD subjects, with a smaller annual increase in integrated score index (0.06 vs 0.20; P<0.05).
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