An atom-economical and solvent-free catalytic procedure for the mono-3-alkylation of oxindole with alcohols is described. The reaction is mediated by the in situ generated catalyst from RuCl(3) x xH(2)O and PPh(3) in the presence of sodium hydroxide. The reactions proceed in good to excellent yields with a wide range of aromatic, heteroaromatic, and aliphatic alcohols.
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Jensen et al. (2009) studied this question.