Donepezil (1-benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-yl)methyl-]piperidine), a potent acetylcholine esterase inhibitor, was labelled with [11C]iodomethane by O-methylation of the O-6′-desmethyl precursor. Synthesis, purification and formulation were performed in approximately 30 min with an average specific activity of 39.5 GBq/μmol at EOS. The total activity available for applications was 7.5–11.1 GBq.
No takes yet. Share an insight, caveat, or question.
Vos et al. (2000) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: