The first copper and zinc copromoted trifluoromethylation using trifluoromethanesulfonic anhydride (Tf 2 O) as a trifluoromethylating reagent has been developed. The reaction of alkenes or alkynes with Tf 2 O in the presence of CuX 2 (X = Br, Cl), Zn powder, and 2,2′-bipyridine affords bromo(chloro)trifluoromethylated products in good yields. CuX 2 plays a dual role as the catalyst and halide source, whereas 2,2′-bipyridine acts as both the activation reagent and ligand.
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Ouyang et al. (2020) studied this question.
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