Prolonged treatment with spironolactone in low-renin hyperaldosteronism invariably corrects plasma electrolyte abnormalities and usually lowers blood pressure. 2. Total exchangeable sodium, total body water, extracellular fluid and plasma volumes are reduced; total exchangeable and total body potassium, plasma renin and angiotensin II concentrations are increased. 3. Spironolactone is similarly effective in patients with apparently isolated deoxycorticosterone (DOC) excess; also in suspected mineralocorticoid excess not associated with elevation of aldosterone or DOC. 4. Studies of amiloride reveal similar effectiveness to spironolactone in low-renin hyperaldosteronism and in suspected mineralocorticoid excess.
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Kremer et al. (1973) studied this question.