Development of Chemo-, Regio-, and Enantioselective [2+2+2] Cycloadditions Catalyzed by Cationic Rhodium (I)/BINAP-Type Bisphosphine Complexes

Our research group first demonstrated that cationic rhodium (I) complexes with BINAP-type bisphosphine ligands are versatile new catalysts for highly chemo-, regio-, and enantioselective [2+2+2] cycloadditions. Highly efficient catalytic synthesis of substituted benzenes, cyclophanes, and nitrogen heterocycles was achieved with high chemo- and regioselectivity using these catalysts. Enantioselective variants of these cycloadditions were also developed, which realized efficient catalytic constructions of axial, planar, and central chirality.