Key result
Obstructive sleep apnea was associated with increased carotid intima-media thickness, suggesting it is a more useful indicator of early atherosclerosis than mean platelet volume.
Why the study?
Is carotid IMT or MPV a better marker for early atherosclerosis in patients with obstructive sleep apnea?
Cross-Sectional (n=158)
Is carotid IMT or MPV a better marker for early atherosclerosis in patients with obstructive sleep apnea?
Carotid IMT may be a more useful surrogate marker than MPV for detecting early atherosclerosis in patients with obstructive sleep apnea.
Answers are grounded in this paper and cite their sources.
Carotid IMT may be preferable to MPV for atherosclerosis assessment in OSA; leaves open need for prospective validation.
BACKGROUND Obstructive sleep apnea (OSA) is known to be closely associated with cardiovascular disease. Carotid intima-media thickness (IMT) is widely used for assessment of atherosclerosis. Mean platelet volume (MPV) is a new marker associated with atherothrombosis. In this study, we aimed to detect early atherosclerosis by measuring carotid intima-media thickness and to investigate the relationship between MPV and IMT and OSA severity. MATERIAL AND METHODS The study population consisted of 158 patients who underwent polysomnography and did not have any overt cardiac disease or risk factors. Carotid IMT was measured by ultrasonography. Blood samples were taken for MPV determination. Subjects were divided into 4 groups according to OSA severity: control, mild, moderate, and severe OSA. RESULTS CONCLUSIONS OSA patients appear to have increased carotid IMT suggestive of an atherosclerotic process. Carotid IMT could be a more useful indicator than MPV in these patients. Long-term prospective studies are needed to confirm these results.
No takes yet. Share an insight, caveat, or question.
Sarıoğlu et al. (2017) conducted a cross-sectional in Obstructive sleep apnea (OSA) (n=158). Obstructive sleep apnea vs. Control (no OSA) was evaluated on Carotid intima-media thickness (IMT) and Mean platelet volume (MPV). Obstructive sleep apnea was associated with increased carotid intima-media thickness, suggesting it is a more useful indicator of early atherosclerosis than mean platelet volume.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: