Key result
Surgical reconstruction in patients with severe internal carotid artery stenosis and impaired dynamic cerebral autoregulation significantly increased phase shift from 0.2-0.3 rad preoperatively to 0.9 rad postoperatively (p<0.001).
Why the study?
Does reconstructive surgery improve dynamic cerebral autoregulation in patients with severe internal carotid artery stenosis?
Cohort (n=50)
No
Does reconstructive surgery improve dynamic cerebral autoregulation in patients with severe internal carotid artery stenosis?
Absolute Event Rate: 0.9% vs 0.2%
p-value: p=<0.001
Reconstructive surgery restores impaired dynamic cerebral autoregulation in patients with severe ICA stenosis, suggesting DCA assessment could help risk-stratify and select patients for surgery, particularly asymptomatic ones.
DCA restoration after carotid reconstruction may inform selection in asymptomatic stenosis; hypothesis-generating and requires prospective outcome trials.
Dynamic cerebral autoregulation (DCA) capacity along with the degree of internal carotid artery (ICA) stenosis and characteristics of the plaque can also play an important role in selection of appropriate treatment strategy. This study aims to classify the patients with severe ICA stenosis according to preoperative state of DCA and to assess its dynamics after surgery. Thirty-five patients with severe ICA stenosis having different clinical type of disease underwent reconstructive surgery. DCA was assessed with transfer function analysis (TFA) by calculating phase shift (PS) between Mayer waves of blood flow velocity (BFV) and blood pressure (BP) before and after operation. In 18 cases, regardless of clinical type, preoperative PS on ipsilateral side was within the normal range and did not change considerably after surgery. In other 17 cases preoperative PS was reliably lower both in patients with symptomatic and asymptomatic stenosis. Surgical reconstruction led to restoration of impaired DCA evidenced by significant increase of PS in postoperative period. Our data suggest that regardless clinical type of disease various state of DCA may be present in patients with severe ICA stenosis. This finding can contribute to establishing the optimal treatment strategy, and first of all for asymptomatic patients. Patients with compromised DCA should be considered as ones with higher risk of stroke and first candidates for reconstructive surgery.
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Semenyutin et al. (2017) conducted a cohort in High-Grade Carotid Artery Stenosis (n=50). Surgical reconstruction (carotid endarterectomy or stenting) vs. Preoperative baseline was evaluated on Phase shift (PS) between Mayer waves of blood flow velocity and blood pressure in patients with impaired autoregulation (p=<0.001). Surgical reconstruction in patients with severe internal carotid artery stenosis and impaired dynamic cerebral autoregulation significantly increased phase shift from 0.2-0.3 rad preoperatively to 0.9 rad postoperatively (p<0.001).
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