Key result
Severe obstructive sleep apnea in middle-aged men was associated with significant telomere shortening compared to those without sleep apnea (mean telomere length ratio 0.53 vs 0.70; P=0.01).
Why the study?
Is obstructive sleep apnea syndrome associated with telomere shortening in middle-aged men?
Cross-Sectional (n=161)
Is obstructive sleep apnea syndrome associated with telomere shortening in middle-aged men?
Absolute Event Rate: 0.53% vs 0.7%
p-value: p=0.01
Intermittent hypoxemia due to obstructive sleep apnea syndrome is independently associated with telomere shortening in middle-aged men, suggesting a mechanism for stress-induced premature aging.
OSA severity was associated with shorter telomeres; hypothesis-generating for premature aging mechanisms and requires prospective validation.
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Boyer et al. (2016) conducted a cross-sectional in Obstructive sleep apnea syndrome (n=161). Obstructive sleep apnea syndrome vs. No sleep apnea was evaluated on Telomere length ratio (p=0.01). Severe obstructive sleep apnea in middle-aged men was associated with significant telomere shortening compared to those without sleep apnea (mean telomere length ratio 0.53 vs 0.70; P=0.01).
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