Enhancement and Modulation of Enzymatic Activity through Higher‐Order Structural Changes of Giant DNA–Protein Multibranch Conjugates

A giant DNA leap for enzyme-kind: Giant DNA–protein multibranch conjugates were shown to be composed of a single β-lactamase enzyme (green, see scheme) conjugated to up to four 48.5 kbp lambda phage DNA branches (blue lines). The conjugation of giant DNA induces a two- to fourfold enhancement of the enzymatic activity, which is modulated by changes in the higher-order DNA structure.