Synthesis and antifungal activity of new 1-(2,4-dichloro phenyl)-3-aryl-2-(1H-1,2,4-triazol-1-yl) prop-2-en-1-one derivatives

A series of novel 1-(2,4-dichlorophenyl)-3-aryl-2-(1H-1,2,4-triazol-1-yl) prop-2- en-1-one derivatives were synthesized in good yields by an aldol condensation between 1-(2,4-dichlorophenyl)-2-(1H-1,2, 4-triazol-1-yl) ethanone and an aryl aldehyde. The structures were established through 1H NMR and 13C NMR spectroscopy and elemental analysis. All compounds 4a-l at a concentration of 50 mg/L showed inhibition against the growth of Gibberella zeae, Fusarium oxysporium, Cytospora mandshurica. The title compound 4a displayed high antifungal activities against G. zeae, F. oxysporium, C. mandshurica comparable to hymexazol.