Reaction of zinc 5,15-bis(3,5-di-tert-butylphenyl)porphyrin with S-(trifluoromethyl)-3,7-dinitrobenzothiophene trifluoromethanesulfonate in tetrahydrofuran gave the 10-trifluoromethylated compound as the major product and 2-CF3- and 10,20-di-CF3-porphyrins as the minor products. The direct trifluoromethylation is effective for preparation of longer-wavelength absorbing meso-trifluoromethylated porphyrins and chlorins.
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Tamiaki et al. (1999) studied this question.
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