A new approach for the stereoselective synthesis of 2',3'-dideoxy-6',6'-difluoro-2'-thionucleosides, analogues of highly bioactive L-OddC and 3TC, has been developed via TMSCl/pyridine induced stereoselective Reformatskii-Claisen rearrangement of secondary allyl chlorodifluoroacetate and then a regioselective Pummerer reaction to introduce bases.
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Zheng et al. (2009) studied this question.
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