A cobalt based alloy, MP35N, with excellent mechanical properties has been recently introduced as a material for surgical orthopedic implants. A study was made of local and systemic host response to this material in two different mammal species. The implantation time ranged from one to 12 months. The result of this study indicated: MP35N produces a degree of local tissue response comparable to that of 316L stainless steel. No systemic side effects were observed during the implantation times included in this study.
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Escalas et al. (1975) studied this question.
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