Palladium-, ligand-, and solvent-free synthesis of ynones by the coupling of acyl chlorides and terminal alkynes in the presence of a reusable copper nanoparticle catalyst

Supported copper nanoparticles are utilized for the first time as a highly efficient and reusable catalyst in the coupling of acyl chlorides and terminal alkynes to prepare various ynones. The reaction is carried out under palladium-, ligand-, and solvent-free conditions. The catalyst can be simply recovered and reused several times without significant loss in catalytic activity.