Key result
Neonates with hemodynamically significant patent ductus arteriosus had significantly lower septal E` velocities compared to controls (4.92 vs 7.60 cm/s, p<0.001), indicating left ventricular diastolic dysfunction.
Why the study?
This study aimed to assess diastolic myocardial functions using tissue Doppler imaging in neonates with different degrees of ductal patency during their first week of life.
Does the degree of patent ductus arteriosus patency affect diastolic myocardial function in neonates?
Case-Control (n=50)
No
Does the degree of patent ductus arteriosus patency affect diastolic myocardial function in neonates?
Absolute Event Rate: 4.92% vs 7.6%
p-value: p=<0.001
In neonates with patent ductus arteriosus, the size of the systemic-to-pulmonary communication correlates with increased left-to-right shunt and pulmonary blood flow.
Larger PDA size was associated with greater shunt and pulmonary flow; leaves open impact on neonatal diastolic function.
Background: The present study was an analytic case control study was done and included full and preterm neonates with PDA and respiratory distress. Neonates with no PDA were also included as a control. Aim of the study: This study aimed to assess diastolic myocardial functions in neonates with different degrees of ductal patency in 1st week of life using tissue Doppler imaging. Methods: The study was conducted at neonatal intensive care unit (NICU) in Bab-Sheria hospital, pediatric department, faculty of medicine, Al Azhar University in the period from June 2018 to June 2021. The present work was conducted on fifty Neonates categorized into 3 groups as follow: Haemodynamically significant dusctus arteriosus cases: ductal diameter more than 2.5 mm and left atrium to aorta (LA: AO) ratio more than 1.5. Non haemodynamically significant ductus arteiosus cases: ductal diameter less than 2.5 mm or (LA: AO) ratio less than 1.5 and Non patent dusctus arteriosus ( Control group). Results: Amount of left-to-right shunt will increase according to the size of the systemic-to-pulmonary communication, and it results in an increased pulmonary blood flow which agrees with our study.
No takes yet. Share an insight, caveat, or question.
Khattab et al. (2022) conducted a case-control in Patent ductus arteriosus (n=50). Hemodynamically significant patent ductus arteriosus vs. Non-patent ductus arteriosus (Control) was evaluated on Septal E` velocity (cm/s) (p=<0.001). Neonates with hemodynamically significant patent ductus arteriosus had significantly lower septal E` velocities compared to controls (4.92 vs 7.60 cm/s, p<0.001), indicating left ventricular diastolic dysfunction.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: