fDiCAL JOV,,?(AL was tested for agglutinins against pneumococci and streptococci.No agglutinins were detected at the beginning of this course, but now, after four doses, his blood shows agglutinins for pneumococci in 1 in 40 dilution, and for streptococci in 1 in 80 dilution, thus indicating a definite agglutination response after the oral administration of such a combined vaccine.No toxic symptoms were observed with these doses at weekly intervals.
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Brian Simpson (1936) studied this question.