Henry Louis Gehrig played for the New York Yankees from 1923 to 1939, during which time he became the most famous first baseman in major league history. He is best known for playing 2,130 consecutive games and for the illness that bears his name: «Lou Gehrig's disease» ― amyotrophic lateral sclerosis (ALS)
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Kasarskis et al. (1989) studied this question.