Abstract 1‐Alkyl(aryl)quinolinium chlorides are oxidized by rabbit liver aldehyde oxidase at positions C‐2 and C‐4. The site and the maximum rate of oxidation are dependent on the size and the steric conformation of the N‐1 substituent. The presence of a 3‐carboxamido group directs the oxidation completely to position C‐4, irrespective of the size of the N‐substituent. Application of covalent amination in liquid ammonia as an “enzyme model” for the oxidation of these compounds shows little resemblance.
No takes yet. Share an insight, caveat, or question.
Angelino et al. (1984) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: