Copper‐Catalyzed Azide–Alkyne Cycloaddition: Regioselective Synthesis of 1,4,5‐Trisubstituted 1,2,3‐Triazoles

Clicking along nicely: Few methods have been reported to be an efficient entry to trisubstituted triazoles with high regioselectivity. This challenge has inspired a search for new reactivity and the development of new chemical approaches. The development of an efficient, robust, one-pot procedure as a route to highly decorated trisubstituted triazoles will be an added bonus to the range of click reactions (see scheme).