Key result
In a patient with primary cardiac angiosarcoma and multiple metastases, brain radiotherapy combined with anlotinib achieved intracranial control with a progression-free survival of 5 months and an overall survival of 12 months.
Why the study?
Primary cardiac angiosarcoma is a fatal disease with poor prognosis, and whether survival can be improved with additional treatment beyond complete surgical excision remains controversial.
Case Report (n=1)
No
In a single case of metastatic primary cardiac angiosarcoma, anlotinib combined with brain radiotherapy provided good intracranial control but did not substantially prolong overall survival.
Primary cardiac angiosarcoma (PCA) is a relatively rare and fatal disease with poor prognosis. It remains controversial whether its survival can be improved with additional treatment besides complete surgical excision. In this case,we presented a 52-year-old man with PCA in the right atrial who underwent a palliative resection, but suffered from metastases of the brain, lung and liver rapidly. He accepted multi-mode combination therapy including first-line chemotherapy, second-line anlotinib which was not only concurrent with brain radiotherapy but also concurrent with immunotherapy in the end. Although anlotinib combined with brain radiotherapy had a effectively control on the intracranial lesions, progression free survival was 5 months. But overall survival didn’t significantly prolonged, for he only survived for 12 months. In conclusion, the treatment for those metastatic PCA still needs further exploration.
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Ma et al. (2023) conducted a case report in Primary cardiac angiosarcoma with multiple metastases (n=1). Brain radiotherapy and anlotinib was evaluated on Progression-free survival and overall survival. In a patient with primary cardiac angiosarcoma and multiple metastases, brain radiotherapy combined with anlotinib achieved intracranial control with a progression-free survival of 5 months and an overall survival of 12 months.
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