Synthesis of Cribrostatin 6 and Its Related Compounds

The synthesis of cribrostatin 6 (1), which shows good biological activity as a dark blue cancer cells growth inhibitor and a number of pathogenic bacteria and fungi, was achieved in two steps from 1-acetylaminomethyl-5,7-diethoxy-8-hydroxy-6-methylisoquinoline ( 14).The related compounds (8~11) were also synthesized, and the antimicrobial activities of 1 and its nine