Key result
Low-dose aspirin intake was significantly associated with increased odds of osteoarthritis compared to no aspirin use (OR 1.14).
Why the study?
Low-dose aspirin is widely used for cardiovascular prevention, but its impact on articular cartilage remains controversial.
Does low-dose aspirin intake increase the risk of osteoarthritis in the general population?
Cross-Sectional (n=12,215)
Does low-dose aspirin intake increase the risk of osteoarthritis in the general population?
Chronic low-dose aspirin intake may be associated with an increased risk of osteoarthritis, highlighting a potential non-cardiovascular adverse effect.
May prompt OA risk discussion for chronic low-dose aspirin users; leaves open causality pending prospective studies.
Objectives: Low-dose aspirin is widely used as a preventive medication for cardiovascular diseases. However, there is controversy regarding the impact of low-dose aspirin on articular cartilage. The aim of this study is to explore the association between low-dose aspirin intake and osteoarthritis (OA). Methods: We conducted a cross-sectional study based on the United States population data from the National Health and Nutrition Examination Survey (NHANES) 2011-2018. The investigation of low-dose aspirin intake and the diagnosis of OA was based on self-reporting in questionnaires. Multivariate regression models was used to assess the relationship between low-dose aspirin intake and OA. In addition, subgroup and interaction analysis were performed to assess the robustness of the results. A significant and consistent association of low-dose aspirin intake with OA was still observed in each subgroup stratified by gender, age, and the presence of comorbidities including diabetes, coronary heart disease, hypertension, and stroke. The results illustrated that the relationship between low-dose aspirin intake and OA was stable in all subgroups and had no interaction. Conclusion: Our study confirmed that low-dose aspirin intake may increase the risk of OA. Attention should be paid to the possibility of joint degenerative changes in patients who take low-dose aspirin chronically. However, further studies are needed to explore the possible mechanisms behind this association.
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Xiong et al. (2024) conducted a cross-sectional in Osteoarthritis (n=12,215). Low-dose aspirin vs. No aspirin use was evaluated on Osteoarthritis (OR 1.14, 95% CI 1.01-1.28, p=0.035). Low-dose aspirin intake was significantly associated with increased odds of osteoarthritis compared to no aspirin use (OR 1.14).
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